What is Retatrutide?

Retatrutide is a next generation peptide that hits three targets instead of one.

Where Ozempic (semaglutide) is a pure GLP-1 receptor agonist, Retatrutide is a triple agonist — working on:

✅ GLP-1 — improves insulin sensitivity, reduces appetite, slows stomach emptying

✅ GIP (Glucose-dependent insulinotropic peptide) — enhances insulin secretion, may preserve beta cells, and appears to help prevent the dreaded “weight plateau” seen with GLP-1 alone

✅ Glucagon receptor — promotes fat metabolism and increases energy expenditure

This means that not only does Retatrutide regulate blood sugar and suppress appetite like Ozempic — it also burns more fat and preserves more muscle while you lose weight.

Why is it better?

The research so far is incredibly promising.

In clinical trials:

???? People on Retatrutide lost up to 24% of their body weight at 48 weeks, compared to 15–16% on semaglutide.

???? Retatrutide improved inflammatory markers more significantly, which is key when you’re also dealing with something like Crohn’s.

???? Retatrutide appeared to have less of a “weight loss ceiling” — meaning weight loss continued longer, without as much early plateauing.

???? Some early data even suggest better maintenance of lean body mass, which is crucial for overall metabolic health and avoiding the frailty that can come with chronic conditions.

But weight loss isn’t the whole story…

What excites me most about Retatrutide is what it means for inflammation and metabolic health.

Crohn’s disease and endometriosis, for example, are inflammatory conditions that wreak havoc on your metabolism. Many people with Crohn’s struggle with high blood sugar, visceral fat, and impaired healing — even if they’re technically “slim.”

By improving insulin sensitivity, calming inflammation, and preserving muscle mass while encouraging fat loss, Retatrutide could help restore a healthier baseline.

It’s a whole-body metabolic reset — not just a crash diet in a pen.

Is it safe?

So far, Retatrutide’s safety profile looks similar to Ozempic — mostly mild, GI-related side effects that tend to improve over time. And because it’s still in late-stage trials, it’s being monitored very closely.

As with any peptide or medication, it’s not about picking it up online or copying what a friend’s doing — it’s about personalisation, the right dosing schedule, and professional support.

That’s why I offer private consultations, where we can look at your full health picture, your goals, and whether something like Retatrutide is right for you.

If you’re tired of short-term fixes… if you want a smarter, evidence-based approach to healing your metabolism and calming your inflammation from the inside out…

???? Book your peptide consultation with me today and let’s build a plan that actually works for you.

Click here to book